Research definitionClinical practice of sublingual immunotherapy in the U.S. dates back more than 100 years with recent research validating what has been observed clinically for decades.

A large number of controlled clinical trials in Europe have shown the effectiveness of sublingual immunotherapy in the treatment of allergic rhinitis and asthma for single antigens. More studies are underway in the U.S. and globally, including studies that explore food allergies. Additional research has shed light on the mechanisms behind sublingual immunotherapy, notably the unique role dendritic cells under the tongue play in building allergen tolerance.